- The film opens with Michael Morbius being awarded a Nobel Prize for his involvement in medical research. During his acceptance speech, he faints.
Morbius - The film cuts to black and then cuts to Michael as a young child at school being bullied because he can't walk. This is then broken up by Emil Nikos (Jared Harris) who is a doctor working at the school.
- Cut to adult Michael having a discussion with Nikos, explaining that his disease is getting worse and he suspects he doesn't have long to live. He thanks Nikos for sticking with him throughout his life.
- Cut to young Michael in a hospital ward playing chess against Nikos. Nikos encourages Michael to peruse becoming a doctor and finding a cure for his disease. Nikos is then told he has to see another patient and Michael continues playing chess by himself.
- Cut to Michael in hospital in New York helping a young girl who has cancer, he then goes to take his medication. He is stopped by Loxias Crown (Matt Smith) who Michael doesn't know. Crown gives him a briefcase and his card. He tells Michael that these may help him find a cure.
- Cut to Michael being injected his medication by his wife, Martine Bancroft (Adria Arjona). During this scene, Michael explains once again how he suspects he doesn't have long to live.
- Michael and Bancroft walk to their lab. Michael says he needs to try more radical ways to cure himself. Michael opens the briefcase. Inside is a dead bat and a giant knife looks more like a machete. Michael is confused but studies the bat and find out it's a vampire bat but nothing else.
- Once Bancroft leaves, Michael calls Crown and asks about the artifacts. Crown explains that he once suffered from the same disease and tells him about a cave in Brazil.
- Michael tells Bancroft that he needs to go to this cave so he can be cured. Bancroft warns against it but Michael doesn't listen.
- Cut to Michael in a helicopter on the way to the cave. There's a voiceover from Crown while this is happening, explaining what Michael has to do. Once he arrives he pays everyone off. Some kind of machine opens up from the ground and Michael cuts his hand and presses it against these strings within the machine. Bats fly towards his hand and then outside the cave, killing everyone else that was in the helicopter. Michael passes out. Cut to black.
- Cut back to Michael waking up. He wanders Brazil for a bit then sneaks onto a cargo ship headed to New York. He starts hiding and shivering. He's slowly transforming into a vampire. He also eats a live rat.
- The ship is attacked by pirates. This is the film's first real action scene. Morbius starts killing off the pirates. Throughout this scene, he's obscured by shadow or it's a POV shot. It reminded me of a scene out of the Alien franchise. We only get a good look at him at the end of the scene and it's the shot from the trailers. Morbius then jumps off the ship and starts swimming.
- Michael wakes up back in New York and not sure what happened. Michael crawls into a bar and tells the bartender to call an ambulance. During this scene, Michael watches the TV and its none other than J Jonah Jameson (J.K Simmons) talking about dead bodies mysteriously found on a cargo ship. Michael then gets flashbacks.
- The ambulance arrives and he's rushed back to the hospital he works and tells everyone that he was mugged and his crutches were stolen. Once he's in his lab, he tells Bancroft and Nikos what really happened and he locks himself in containment to protect them.
- Michael's thirst for blood becomes too strong and he breaks out. Bancroft and Nikos escape but he runs after a doctor/nurse working there and is shot by security guards. Bancroft then injects Morbius with something and he's knocked out.
- Michael wakes up in his lab and finds a tomb there. There's a note on it that says "All the answers you seek lie within - Loxias" Michael opens it to find a skeleton wearing a comic accurate Morbius suit which Michael laughs at. The tomb is also covered in some ancient language and Michael doesn't know how but he's able to read it.
- Cut to Simon Stroud (Tyrese Gibson) investigating what caused the death of the pirates. Simon believes it was something supernatural that caused it which the others laugh off. Simon also has a mechanical gauntlet on his right arm that gives him super strength in that arm. It's mentioned that the gauntlet is from Oscorp.
- Meanwhile, there's a montage of Michael testing out his new abilities, a lot of this is seen in the trailers.
- Simon visits Emil Nikos and starts asking him questions about Michael.
- Meanwhile, Loxias Crown is in some kind of lab in the sewers and revealed to be incredibly skinny and has tattoos all over his body. He collapses.
- Cut to the tomb in Michael's lab opening itself up. The skeleton in it starts fighting Morbius. This is the best scene in the movie just because of how bonkers it is. Morbius defeats it by crushing its skull and then the skeleton's costume attaches itself to Morbius.
- Loxias wakes up and casts some kind of spell on himself. He then walks onto some train tracks and stops a train with his weird magic spell. He then sucks the life out of everyone onboard until he regains his strength and looks like normal Matt Smith.
- Loxias senses that Simon Stroud is going to ruin his plan and he possesses Morbius, who flies over to Niko's house to kill Stroud. Stroud is able to put up a fight with Morbius because of his gauntlet and Nikos is killed during the fight, leading Michael to snap out of it. Michael allows Stroud to arrest him.
- He's sent to San Quentin State Prison and his inmate is Adrien Toomes (Michael Keaton) who makes a joke about how him getting blipped technically meant he got a shorter sentence.
- During the night Michael sees Loxias Crown in some kind of ghost form and tells Michael to meet him in New York or he'll kill Martine Bancroft. Michael builds up his power and breaks out of the prison while floating and being surrounded by bats. This somehow leads to all electricity being cut off within the prison and everyone is set free. A prison riot ensues.
- Toomes climbs out of the prison while Michael uses his powers against prison guards and steals a coat from one of them. Toomes thanks Michael for breaking him out and tells him he's putting a team together (Sinister Six) and wants Michael to join. Michael declines and uses his super-speed to take him to New York.
- We also see Mac Gargan (Michael Mando) break out and meet up with Toomes. Cletus Kasady (Woody Harrelson) also runs off. Thankfully his hair no longer resembles Sideshow Bob and looks more like a mop and slightly less red. It still looks like a wig but it's better than what he had in Venom.
- Morbius finds Loxias Crown in New York, who reveals that the skeleton was once him and he's reincarnation and he needs Morbius to complete a ritual so he can live forever without reincarnating and become all-powerful.
- Morbius's costume forms around him and he fights Loxias. They're mostly flying the whole time, the fight reminded me of a lot of the fight from the end of the Chronicle. Morbius is able to defeat Crown by reading one of his tattoos, which allows him to suck the life out of Crown. Morbius grows until he's 9ft tall and starts roaring at everyone around but Bancroft calms him down until he's normal Michael again.
- Michael escapes before the police arrive and take off his costume. On the way he passes the Spider-Man poster tagged "MURDERER" and unlike in the trailer the picture used resembles the Homecoming suit instead of the Raimi suit.
- The film ends with Michael and Bancroft at Niko's funeral while Stroud watches in the distance. Cut to Morbius jumping across New York. The final shot is Morbius on a billboard showing a Peter Parker WANTED sign.
- Sad Part there's no end credit scenes.